It’s been nearly a month since the last Think and Drink (we took a week off due to spring break) and there have been a few changes to our plans. Our April 6th talk has proved to be quite difficult to schedule. Unfortunately, one of our original speakers had a last minute scheduling conflict, so I (Amanda) will be filling the spot. This means that we will have two oogenesis/early development talks. The first from Julie Merkle of the Schüpbach lab will address fundamental questions in germline regulation and gamete formation in Drosophila. My talk will deal with the long standing problem of DNA-to-cytoplasm ratio sensing during the Mid-Blastula Transition in Xenopus with just a bit of our more recent Drosophila work.